Publications

After 2012 (*corresponding author)

  1. Eyo UB, Peng J, Murugan M, Mo M, Lalani A, Xu P, Xie P, Margolis D, Wu LJ*. 2017. Regulation of physical microglia-neuron interactions by fractalkine signaling after status epilepticus, eNeuro, 3(6): 1-14. PDF
  2. Liu Y#, Zhou LJ#, Wang J#, Li D, Ren WJ, Peng J, Wei X, Xu T, Xin WJ, Pang RP, Li YY, Qin ZH, Murugan M, Mattson MP, Wu LJ*, Liu XG*. 2017. TNF-α differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury. Journal of Neuroscience, 37(4): 871-881. PDF
  3. Eyo UB, Murugan M, Wu LJ*. 2017. Microglia-neuron communication in epilepsy. Glia, 65(1): 5-18 (review). PDF
  4. Gu N#, Peng J#, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H*, Wu LJ*. 2016. Spinal microgliosis due to resident microglial proliferation is required for pain hypersensitivity after peripheral nerve injury. Cell Reports, 16(3): 605-614. PDF
  5. Peng J#, Gu N#, Zhou LJ, Eyo UB, Murugan M, Gan WB, Wu LJ*. 2016. Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. Nature Communications, 7:12029. PDF.
  6. Tian D, Li C, Qin C, Murugan M, Wu LJ*, Liu J*. 2016. Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke, Journal of Neurochemistry, 139(1): 96-105. PDF
  7. Gui WS, Wei X, Mai CL, Murugan M, Wu LJ, Xin WJ, Zhou LJ, Liu XG*. 2016. Overproduction of interleukin-1β in injured sciatic nerve is a common pathological mechanism for neuropathic pain, memory deficit and depression in rodents with spared nerve injury. Molecular Pain, 12: 1-15. PDF
  8. Swiatkowski P#, Murugan M#, Eyo UB, Wang Y, Rangaraju S, Oh SB, Wu LJ*. 2016. Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury. Neuroscience, 318:22-33. PDF
  9. Jeong H, Na YJ, Lee K, Kim YH, Lee Y, Kang M, Jiang BC, Yeom YI, Wu LJ, Gao YJ, Kim J, Oh SB*. 2016. High-resolution transcriptome analysis reveals neuropathic pain gene expression signatures in spinal microglia following nerve injury. Pain, 157 (4):964-976. PDF
  10. Gu N#, Eyo UB#, Murugan M, Peng J, Matta S, Dong H*, Wu LJ*. 2016. Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. Brain, Behavior and Immunity, 55: 82-92. PDF
  11. Zeng WZ, Liu DS, Liu L, She L, Wu LJ*, Xu TL*. 2015. Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling. Scientific Reports, 5:14125. PDF
  12. Liu J, Tian D, Murugan M, Eyo UB, Dreyfus CF, Wang W, Wu LJ*. 2015. Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage. Journal of Neurochemistry, 135(2):347-356. PDF
  13. Xu P, Xu Y, Hu B, Wang J, Pan R, Murugan M, Wu LJ, Tang Y*. 2015. Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor. Brain, Behavior and Immunity, 50: 87-100. PDF
  14. Eyo UB, Gu N, De S, Dong H, Richardson JR, Wu LJ*. 2015. Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium. Journal of Neuroscience, 35(6): 2417-2422. PDF
  15. Wu LJ*. 2014. Voltage-gated proton channel Hv1 in microglia. Neuroscientist, 20 (6): 599-609 (review). PDF
  16. Wu LJ*. 2014. Microglial voltage-gated proton channel Hv1 in ischemic stroke. Translational Stroke Research, 5 (1): 99-108 (review). PDF
  17. Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ*. 2014. Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. Journal of Neuroscience, 34(32): 10528-10540. PDF
  18. Wu LJ*, Stevens B, Duan S, MacVicar BA. 2013. Microglia in neuronal circuits. Neural Plasticity, 2013: 586426 (editorial). PDF
  19. Eyo UB, Wu LJ*. 2013. Bi-directional microglia-neuron communication in the healthy brain. Neural Plasticity, 2013: 456857 (reivew). PDF
  20. Eyo UB, Miner SA, Ahlers KE, Wu LJ, Dailey ME*. 2013. P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation. Neuropharmacology, 73C: 311-319. PDF

Before 2012 (#equal contribution) 

  1. Wu LJ#, Wu G#, Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. 2012. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nature Neuroscience, 15(4): 565-573. (Highlighted by Nature Reviews Neurology, 2012, 8:179) PDF
  2. Koga K, Sim SE, Chen T, Wu LJ, Kaang BK, Zhuo M. 2012. Kainate receptor-mediated synaptic transmissions in the adult rodent insular cortex. Journal of Neurophysiology, 108(7):1988-1998. PDF
  3. Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. 2012. The channel kinase, TRPM7, is required for early embryonic development. Proceedings of the National Academy of Science, USA, 109(5): E225-233. PDF
  4. Zhuo M, Wu G, Wu LJ. 2011. Neuronal and microglial mechanisms of neuropathic pain. Molecular Brain, 4 (1): 31 (review). (Highlighted ashighly accessed article”) PDF
  5. Toyoda H, Li X, Wu LJ, Zhao MG, Descalzi G, Chen T, Koga K and Zhuo M. 2011. Interplay of amygdala and cingulate plasticity in emotional fear. Neural Plasticity, 2011:813749 (review). PDF
  6. Suzuki A, Fukushima H, Mukawa T, Toyoda H, Wu LJ, Zhao MG, Xu H, Shang Y, Endoh K, Iwamoto T, Mamiya N, Okano E, Hasegawa S, Mercaldo V, Zhang Y, Maeda R, Ohta M, Josselyn SA, Zhuo M, Kida S. 2011 Upregulation of CREB-mediated transcription enhances both short- and long-term memory. Journal of Neuroscience, 31(24): 8786-8802. PDF
  7. Kim SS, Wang H, Li XY, Chen T, Mercaldo V, Descalzi G, Wu LJ, Zhuo M. 2011. Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice. Molecular Brain, 4 (1): 6 PDF
  8. Wang H#, Xu H#, Wu LJ#, Kim SS#, Chen T, Koga K, Descalzi G, Gong B, Vadakkan KI, Zhang X, Kaang BK, Zhuo M. 2011. Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain. Science Translational Medicine, 3 (65): 65ra3. (Highlighted by Nature Reviews Drug Discovery, 2011, 10:176; Commented by Science Translational Medicine, 2011, 3:65ps1; Evaluated by Faculty of 1000) PDF
  9. Wu LJ#, Sweet TB#, Clapham DE. 2010. Current progress in the mammalian TRP ion channel family. Pharmacological Reviews, 62 (3): 381-404 (review). PDF
  10. Cao XY, Mercaldo V, Li P, Wu LJ, Zhuo M. 2010. Facilitation of the inhibitory transmission by gastrin-releasing peptide in the anterior cingulate cortex. Molecular Pain, 6 (1): 52. PDF
  11. Slusky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G. 2010. Enhancement of learning and memory by elevating brain magnesium. Neuron, 65 (2): 165-177. (Highlighted by Neuron, 2010, 65:143-4) PDF
  12. Wu LJ#, Mellstrom B#, Wang H#, Ren M#, Domingo S, Kim SS, Li XY, Chen T, Naranjo JR, Zhuo M. 2010. DREAM (Downstream Regulatory Element Antagonist Modulator) contributes to synaptic depression and contextual fear memory. Molecular Brain, 3 (1): 3. PDF
  13. Wu LJ, Zhuo M. 2009. Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain. Neurotherapeutics, 6 (4): 693-702 (review). PDF
  14. Wu LJ, Wang YT, Zhuo M. 2009. Hook-up of GluA2, GRIP and liprin-alpha for cholinergic muscarinic receptor-dependent LTD in the hippocampus. Molecular Brain, 2 (1): 17 (review). PDF
  15. Cao XY#, Xu H#, Wu LJ#, Li X, Chen T, Zhuo M. 2009. Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice. Molecular Pain, 5 (1): 73. PDF
  16. Wu LJ, Li X, Chen T, Ren M, Zhuo M. 2009. Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording. Molecular Brain, 2 (1): 32. PDF
  17. Toyoda H, Zhao M, Ulzhofer B, Wu LJ, Xu H, Seeburg P, Sprenget S, Kuner R, Zhuo M. 2009. Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex. Molecular Pain, 5 (1): 46. PDF
  18. Wu LJ#, Kim SS#, Li X#, Zhang F#, Zhuo M. 2009. Sexual attraction enhances glutamate transmission in mammalian anterior cingulate cortex. Molecular Brain, 2 (1): 9. PDF
  19. Fukushima H, Maeda R, Suzuki R, Suzuki A, Nomoto M, Toyoda H, Wu LJ, Xu H, Zhao MG, Ueda K, Kitamoto A, Mamiya N, Yoshida T, Homma S, Masushige S, Zhuo M, and Kida S. 2008. Up-regulation of CaMKIV improves memory formation and rescues memory loss with aging. Journal of Neuroscience, 28 (19): 9910-9919. (Evaluated by Faculty of 1000) PDF
  20. Wu LJ, Kim SS, Zhuo M. 2008. Molecular targets of anxiety: from membrane to nucleus. Neurochemical Research, 33 (10): 1925-1932 (reveiw). PDF
  21. Zhang XH, Wu LJ, Gong B, Ren M, Li BM, Zhuo M. 2008. Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear in the hippocampal CA1 region of rats. Molecular Brain, 1 (1): 9. PDF
  22. Wu LJ, Steenland HK, Kim SS, Isiegas C, Ted A, Kaang BK, Zhuo M. 2008. Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex. Molecular Pain, 4 (1): 40. PDF
  23. Wang H#, Wu LJ#, Kim SS#, Lee FJ, Gong B, Toyoda H, Ren M, Xu H, Liu F, Zhao MG, Zhuo M. 2008. FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron, 59 (4): 634-647. (Highlighted by Nature, 2008, 455: 266; Commented by Nature, 2008, 455: 607-8) PDF
  24. Xu H#, Wu LJ#, Wang H#, Zhang X, Vadakkan KI, Kim SS, Steenland HW, Zhuo M. 2008. Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. Journal of Neuroscience, 28 (29): 7445-7453. PDF
  25. Ko S, Wu LJ, Shum F, Quan J, Zhuo M. 2008. Cingulate NMDA NR2B receptors contribute to morphine-induced analgesia tolerance. Molecular Brain, 1 (1): 2. PDF
  26. Hines RM#, Wu LJ#, Hines DJ, Steenland H, Mansour S, Dahlhaus R, Singaraja RR, Cao X, Sammler E, Hormuzdi SG, Zhuo M, El-Husseini A. 2008. Synaptic imbalance, stereotypies and impaired social interactions in mice with altered neuroligin 2 expression. Journal of Neuroscience, 28 (24): 6055-6067. (Highlighted by “This Week in The Journal”) PDF
  27. Isiegas C, McDonough C, Huang T, Fabian S, Wu LJ, Xu H, Zhao MG, Kim JI, Lee YS, Lee HR, Ko HG, Lee N, Son H, Zhuo M, Kaang BK, Abel T. 2008. A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. Journal of Neuroscience, 28 (24): 6020-6030. (Highlighted by “This Week in The Journal”; Evaluated by Faculty of 1000) PDF
  28. Wang H, Wu LJ, Zhang F, Zhuo M. 2008. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by Group I metabotropic glutamate receptors. Journal of Neuroscience, 28 (17): 4385-4397. PDF
  29. Zhang F, Vadakkan K, Kim SS, Wu LJ, Shang Y, Zhuo M. 2008. Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse. Molecular Pain, 4 (1): 15. PDF
  30. Wu LJ#, Zhang XH#, Fukushima H, Zhang F, Wang H, Toyoda H, Li BM, Kida S, Zhuo M. 2008. Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. European Journal of Neuroscience, 27 (8): 1923-1932. PDF
  31. Wu LJ, Zhuo M. 2008. Resting microglial motility is independent of synaptic plasticity in mammalian brain. Journal of Neurophysiology, 99 (4): 2026-2032. PDF
  32. Wu LJ#, Ren M#, Wang H#, Kim SS, Cao X, Zhuo M. 2008. Neurabin contributes to hippocampal long-term potentiation and contextual fear memory. PLoS ONE, 3 (1): e1407. PDF
  33. Du J, Creson TK, Wu LJ, Ren M, Gray NA, Falke C, Wei Y, Wang Y, Blumenthal R, Machado-Vieira R, Yuan P, Chen G, Zhuo M, Manji HK. 2008. The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. Journal of Neuroscience, 28 (1): 68-79. (Highlighted by “This Week in The Journal”) PDF
  34. Wu LJ, Ko S, Zhuo M. 2007. Kainate receptor and pain: from dorsal root ganglion to the anterior cingulate cortex. Current Pharmaceutical Design, 13 (15): 1597-1605 (review). PDF
  35. Toyoda H, Zhao MG, Xu H, Wu LJ, Ren M Zhuo M. 2007. Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex. Molecular Pain, 3 (1): 36. PDF
  36. Duan B#, Wu LJ#, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL. 2007. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. Journal of Neuroscience, 27 (41): 11139-11148. PDF
  37. Wu LJ, Vadakkan KI, Zhuo M. 2007. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia, 55 (8): 810-821. PDF
  38. Toyoda H#, Wu LJ#, Zhao MG#, Xu H, Jia Z, Zhuo M. 2007. Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex. Journal of Cellular Physiology, 211 (2): 336-343. PDF
  39. Wu LJ, Xu H, Ren M, Cao X, Zhuo M. 2007. Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex. Molecular Pain, 3 (1): 11. PDF
  40. Shum F, Wu LJ, Zhao MG, Toyoda H, Xu H, Ren M, Pinaud R, Ko S, Lee YS, Kaang BK, Zhuo M. 2007. Alterations of long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learning & Memory, 14 (4): 304-312. PDF
  41. Toyoda H#, Wu LJ#, Zhao MG#, Xu H, Zhuo M. 2007. Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation. Developmental Neurobiology, 67 (4): 498-509. PDF
  42. Wu LJ, Xu H, Ren M, Zhuo M. 2007. Genetic and Pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult mice. Developmental Neurobiology, 67 (2): 146-157. PDF
  43. Wu LJ#, Ko S#, Toyoda H#, Zhao MG#, Xu H, Vadakkan KI, Ren M, Knifed E, Shum F, Quan J, Zhang XH, Zhuo M. 2007. Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice. PLoS ONE, 2 (1): e167. PDF
  44. Wu LJ, Zhuo M. 2006. Supraspinal electrophysiological models for studying chronic pain. Drug Discovery Today: Disease Models, 3 (4): 405-411(review). PDF
  45. Steenland HW, Ko S, Wu LJ, Zhuo M. 2006. Hot receptors in the brain. Molecular Pain, 2 (1): 34 (review). (Highlighted ashighly accessed article”) PDF
  46. Zeng H, Gragerov A, Hohmann JG, Pavlova MN, Schimpf BA, Xu H, Wu LJ, Toyoda H, Zhao MG, Rohde AD, Gragerova G, Onrust R, Bergmann JE, Zhuo M, Gaitanaris GA. 2006. Neuromedin U receptor 2 deficient mice display differential responses in sensory perception, stress and feeding. Molecular and Cellular Biology, 26 (24): 9352-9363. PDF
  47. Blaeser F, Sanders MJ, Truong N, Ko S, Wu LJ, Wozniak DF, Fanselow MS, Zhuo M, Chatila TA. 2006. Long term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase a-deficient mice. Molecular and Cellular Biology, 26 (23): 9105-9115. PDF
  48. Xu H#, Wu LJ#, Zhao MG, Toyoda H, Vadakkan KI, Jia Y, Zhuo M. 2006. Presynaptic regulation of inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Molecular Pain, 2 (1): 29. PDF
  49. Zhao MG#, Ko S#, Wu LJ#, Toyoda H#, Xu H, Quan J, Jia Y, Li JG, Ren M, Xu Z, Zhuo M. 2006. Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of the mice with chronic pain. Journal of Neuroscience, 26 (35): 8923-8930. PDF
  50. Ko S, Jia Y, Xu H, Holdridge S, Yim S, Jang DH, Lee YS, Zhao MG, Toyoda H, Wu LJ, Chatila T, Cahill C, Kaang BK, Zhuo M. 2006. Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. European Journal of Neuroscience, 23 (8): 2158-2168. (Evaluated by Faculty of 1000) PDF
  51. Wei F, Vadakkan KI, Toyoda H, Wu LJ, Zhao MG, Xu H, Shum F, Jia Y, Zhuo M. 2006. Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice. Journal of Neuroscience, 26 (3): 851-861. PDF
  52. Wu LJ, Xu H, Ko S, Yoshimura M, Zhuo M. 2005. Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P. Molecular Pain, 1 (1): 34 (review). PDF
  53. Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko S, Jia Y, Shum F, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo M. 2005. Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. Journal of Neuroscience, 25 (48): 11107-11116. PDF
  54. Zhao MG#, Toyoda H#, Lee YS#, Wu LJ#, Ko S#, Zhang XH#, Jia Y, Shum F, Xu H, Li BM, Kaang BK, Zhuo M. 2005. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron, 47 (6): 859-872. PDF
  55. Zhao MG, Toyoda H, Ko S, Ding HK, Wu LJ, Zhuo M. 2005. Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. Journal of Neuroscience, 25 (32): 7385-7392. PDF
  56. Liauw J, Wu LJ, Zhuo M. 2005. Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex. Journal of Neurophysiology, 94 (1): 878-882. PDF
  57. Wu LJ, Zhao MG, Toyoda H, Ko S, Zhuo M. 2005. Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex. Journal of Neurophysiology, 94 (3): 1805-1813. PDF
  58. Gao J, Wu LJ, Xu L, Xu TL. 2004. Properties of proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neurons. Brain Research, 1017 (1-2): 197-207. PDF
  59. Wu LJ, Duan B, Mei YD, Gao J, Chen JG, Zhuo M, Xu L, Wu M, Xu TL. 2004. Characterizations of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. Journal of Biological Chemistry, 279 (42): 43716-43724. PDF
  60. Li Y, Wu LJ, Legendre P, Xu TL. 2003. Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. Journal of Biological Chemistry, 278 (40): 38637-38645. PDF
  61. Li YF, Wu LJ, Li Y, Xu L, Xu TL. 2003. Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons. Journal of Physiology (London),552 (Pt 1): 73-87. PDF
  62. Xu TX, Lu H, Wang Q, Wu LJ, Liu J, Zhou Z, Xu TL. 2002. Properties of whole-cell potassium currents in mechanically dissociated Drosophila larval central neurons. Acta Physiologica Sinica, 54 (5): 411-416. PDF
  63. Wu LJ, Li Y, Xu TL. 2002. Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons. NeuroReport, 13 (7): 977-981. (Highlighted by Current Opinion in Pharmacology, 2004, 4:47-52) PDF
  64. Wu LJ, Lu Y, Xu TL. 2001. A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons. Journal of Neuroscience Methods, 108 (2): 199-206. PDF